From Soil to Cell: The Biological Resilience Policymakers Ignore

By Francesca Orsini

Leggi l’articolo in italiano

There is a methodological paradox linking the management of environmental public policy with the traditional approach to public health. Both systems suffer from the same managerial pathology: what we might call the “mechanic’s syndrome.” We wait for the engine to seize before changing the oil; we wait for an agricultural ecosystem to collapse before questioning intensive monoculture; we wait for a patient to develop overt inflammatory disease or organ damage before intervening in their biological trajectory.

This logic of reacting after the fact is not only scientifically inefficient; it is financially and socially unsustainable. We spend billions managing climate-related emergencies while continuing to devote a predominant share of healthcare resources to managing disease once it has already manifested, with comparatively fewer resources directed toward prevention and the early identification of vulnerability. In short, we heavily finance the consequences of damage while undervaluing the silent vulnerabilities that precede it.

Reversing this dynamic is not an ideological preference. It is a structural necessity that requires a profound transition toward policy models built around resilience and anticipation.

In a nutshell:

  • Sustainability starts before damage occurs, not just with repairing it: investing in the resilience of organisms and ecosystems strengthens their ability to withstand stress without collapsing.
  • Food connects human health and agricultural systems: it influences biological processes in the body, while food choices shape supply chains, resource use and soil health.
  • The real challenge is to identify vulnerabilities early and reduce reliance on emergency responses: this requires investment in research, early diagnostic tools and precision agriculture, while protecting freedom of choice.

The Failure of the “Ex-Post” Economy

In complex systems science, one of the most common mistakes is to intervene on late-stage symptoms rather than strengthening the system before damage occurs.

Public spending reflects a similar tendency to allocate substantial resources toward ex-post restoration. Rebuilding destroyed infrastructure or funding high-tech treatments for advanced cardiovascular disease or cancer is politically immediate, visible, and readily translated into short-term political consensus.

By contrast, investing in soil regeneration to reduce the risk of desertification, or developing tools capable of identifying biological vulnerabilities at an early stage, can generate substantial economic and social returns whose benefits are distributed over much longer time horizons.

True sustainability – whether environmental or health-related – is not measured solely by our ability to repair what has already broken, but by a system’s capacity to absorb stress without collapsing.

From this perspective, anticipation does not replace prevention; it extends its logic, shifting attention from managing known risks toward identifying dynamic vulnerabilities before they become clinically or ecologically manifest damage.

Food as an Epigenetic and Systemic Signal, Beyond Paternalism

As a researcher and nutritionist, I see daily how the debate around food remains trapped in a sterile polarization.

On the one hand, food is reduced to little more than calorie counting or framed primarily as an individual risk factor. On the other, it is increasingly addressed through regulatory approaches that, when they reduce food quality to individual nutrients or aggregate indicators, risk capturing only part of its biological and nutritional complexity.

Scientific evidence points to a more complex picture. Food is not an isolated element but one of the most relevant environmental modulators of metabolic and epigenetic processes.

What we introduce into our bodies is not simply “fuel,” but a complex set of biochemical signals capable of influencing gene expression and multiple epigenetic mechanisms in the host, modulating the gut microbiota, and contributing to the regulation of chronic low-grade inflammatory states implicated in the pathophysiology of numerous non-communicable diseases.

At the same time, our dietary choices feed back into production systems, influencing water-resource use and the biological pressures placed on soils. Progressive biological soil depletion can contribute to changes in the nutritional quality of food, with potential consequences for human nutrition and metabolism.

Human health and the health of agricultural systems are therefore not two parallel tracks that happen to intersect: they are dimensions of the same integrated and circular biological system.

Building Biological and Environmental Resilience

The scientific and regulatory challenge of the coming decades is to develop a genuine science of anticipation. The aim is not to predict with deterministic precision exactly which crisis will occur – an unrealistic ambition when dealing with complex and dynamic systems such as the climate or the human organism – but to reduce the intrinsic susceptibility of those systems before stress produces irreversible consequences.

In medicine, this means developing and validating tools capable of detecting early deviations from health trajectories — integrating, where supported by evidence, metabolomics, microbiota profiling, and inflammatory biomarkers — before the clinical manifestation of disease.

In environmental and market policy, it means reducing our dependence on emergency interventions and building regulatory and economic frameworks that encourage scientific innovation, resource regeneration, and precision agricultural technologies.

Good public policy should not force us to choose between individual freedom and collective prevention. Its role should be to create the conditions in which individuals, healthcare systems, and productive systems can anticipate risk, adapt to stress, and make better-informed choices. From this perspective, resilience becomes the common ground between freedom, public health, and sustainability.

For organizations committed to the critical analysis of public policy, this is the real frontier: defending freedom of choice while promoting investment in resilience before damage occurs, rather than publicly subsidizing its consequences afterwards. As long as we continue to reward emergency response while underfunding anticipation, we will remain trapped in an economy of repair that we can no longer afford.

Latest News